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在(zai)重(zhong)癥炎癥發生(sheng)時，中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)是(shi)起主要(yao)作(zuo)(zuo)用(yong)(yong)的(de)細(xi)胞(bao)，目(mu)前認為這(zhe)種白細(xi)胞(bao)在(zai)調節免疫應答中(zhong)(zhong)扮演著重(zhong)要(yao)的(de)角色。位于(yu)內皮細(xi)胞(bao)表面(mian)或(huo)者胞(bao)外(wai)基質中(zhong)(zhong)的(de)化(hua)(hua)學誘(you)導物能夠(gou)引(yin)導中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)遷移(yi)到患處(chu)，這(zhe)一特(te)性(xing)(xing)(xing)被稱為趨化(hua)(hua)性(xing)(xing)(xing)。動脈(mo)粥樣硬化(hua)(hua)、重(zhong)癥哮喘等(deng)病態條件(jian)能夠(gou)誘(you)發大量的(de)中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)趨化(hua)(hua)性(xing)(xing)(xing)。研究(jiu)這(zhe)些(xie)化(hua)(hua)學信號在(zai)觸(chu)發中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)遷移(yi)中(zhong)(zhong)的(de)作(zuo)(zuo)用(yong)(yong)對于(yu)理解中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)的(de)生(sheng)物學特(te)性(xing)(xing)(xing)是(shi)*的(de)，同時對于(yu)研發新的(de)抗炎藥物治(zhi)療法也是(shi)十分(fen)重(zhong)要(yao)的(de)。盡(jin)管已(yi)經研究(jiu)出一些(xie)方法能夠(gou)評(ping)估中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)趨化(hua)(hua)性(xing)(xing)(xing)，但是(shi)這(zhe)些(xie)技術通常要(yao)么過(guo)于(yu)繁瑣，要(yao)么改變了這(zhe)些(xie)細(xi)胞(bao)的(de)自然狀態和生(sheng)理反應。加拿大蒙特(te)利爾大學的(de)科學家Patricia M等(deng)報道一種根據阻抗作(zuo)(zuo)用(yong)(yong)設計的(de)快(kuai)速、非干預式、無標記的(de)鑒定方法，用(yong)(yong)于(yu)實時評(ping)估中(zhong)(zhong)性(xing)(xing)(xing)粒(li)細(xi)胞(bao)趨化(hua)(hua)性(xing)(xing)(xing)。

原文：

A real-time assay for neutrophil chemotaxis，Patricia M. Cano, Amandine Vargas, and Jean-Pierre Lavoie，BioTechniques 60:245-251 (June 2016)